Mutant gene linked to most severe type of TB

People who carry a mutant gene can develop potentially fatal meningitis if they get infected with the drug resistant Beijing strain of tuberculosis, a study in Vietnam has found.

Tuberculous meningitis is the most severe form of the disease in which the infection spreads to membranes enveloping the brain and the spinal cord. One in three people who develop TB meningitis dies, even if he or she gets hospital treatment.

The study published in the open-access journal PLoS Pathogens (plospathogens.org), found people most likely to develop TB meningitis were those who carried a variant of the TLR2 gene and who get infected with the Beijing TB strain, prevalent in Asia and the former Soviet states.

Previous studies have linked TLR2 to the immune system and it seems to be important for recognising and initiating a defensive response to the TB bacteria.

The researchers took bacteria samples from 187 patients who suffered tuberculous meningitis and 236 other patients who suffered the more common pulmonary tuberculosis.

Most of the patients then had their genes analysed to see if they carried the TLR2 variant.

"Together, these results suggest that the association of the (variant gene) with tuberculous meningitis is strongest among those infected with the Beijing lineage," the scientists wrote.

The "Beijing" family of TB strains is prevalent in Asia and former Soviet states. It has become more drug resistant in recent years and has been responsible for outbreaks of multi-drug resistant tuberculosis in the United States.

More than one-third of the world's population is infected with TB and the infection rate is one every second. However, only one in 10 infected persons will develop symptoms and that usually happens when their immune systems are weak.

Left untreated, TB kills half its victims. The disease kills over 2 million people each year.

One of the researchers, Maxine Caws at the Hospital for Tropical Diseases in Vietnam, said the latest finding was a reason to develop more sophisticated and targeted treatments and vaccines.

"This is particularly important in this era of emerging 'untreatable' bacteria infections due to antibiotic resistance," Caws wrote.

Bones show humans in Europe 1.2 mln years ago

Early humans may have roamed Europe as much as 1.2 million years ago, far earlier than previously thought, scientists said on Wednesday, based on fossils they found in northern Spain.

Researchers excavated a jaw bone, teeth and simple tools in a cave near the city of Burgos dated around 400,000 years older than the previously oldest-known remains found at a nearby site 14 years ago, a paper published in the journal Nature said.

The remains are accurately dated and lay to rest doubts about when early humans first lived in Europe, said Andreu Olle, who has worked at the Atapuerca site since 1990.

"These are the oldest human remains in Europe. With this fossil, we can say it (Europe) was populated earlier than was thought," he told Reuters.

The bones are similar to fossils thought to be 800,000 years old found at the same site in 1994, suggesting a continuous human presence in Western Europe.

Up to now archaeologists had found evidence of human activity in Spain, France and Italy around 1 million years ago but no human remains, only animal bones and stone tools.

Scientists generally agree that modern humans spread out of Africa starting about 50,000 years ago, quickly establishing Stone Age cultures throughout Europe, Asia and Australia.

However the fossil, thought to be from the 'Homo antecessor' species, would have shared common ancestors with modern man and may have mixed with the more recent newcomers from Africa.

Flakes of flint embedded in animal bones, suggesting the use of a crude knife, were amongst the finds discovered at the site last June.

The find adds weight to the theory that early humans spread from Africa via the Middle East, not across the Straits of Gibraltar separating Africa from Europe, because the jaw was a similar shape to one unearthed in the central Asian country of Georgia thought to be 1.7 million years old.